Historically, no . ePSXe classic versions (2.0.5 and earlier) do not support CHD files natively. You would get a "BIOS ROM not found" or "Invalid image file" error.
ePSXe will now load the CHD file. You may see a progress bar indicating that the file is being loaded. epsxe chd files
Warning: This will create much larger files. You will need the matching .cue sheet. You can generate a .cue automatically using a tool like CUE Maker or extract it specifically using chdman extractcd (different command). Historically, no
If you absolutely need ePSXe for a specific plugin or legacy hardware, keep a separate folder of BIN/CUE files. But for everyone else: . Your hard drive will thank you. epsxe chd files