For basic functionality, you don't actually need a driver for the keys . The Axiom Pro 49 is somewhat class-compliant. If you go into the MIDI settings of your DAW, you might see the device appear as a generic MIDI controller. You can play notes and record melodies. However, you will have to manually map every single knob and fader yourself. The automatic "magic" is gone.

No additional drivers are necessary for your Mac to recognize the keyboard and play virtual instruments. Simply plug it in via USB, and it should appear in your DAW.

For professionals who absolutely rely on the HyperControl mapping features, the solution is drastic: don't update your Mac. There is a reason you still see studios running ancient Mac Minos on macOS High Sierra. The Axiom Pro 49 lives comfortably there, with the last official driver (v1.2.2 or similar) installed. It is a digital preservation effort.