The only exception: if your file is truly massive (>50GB) on a 32-bit OS, Helium will still work but may use 64-bit addressing. On 64-bit systems, there’s no theoretical limit.
: The Pro version is available as a portable edition for use without local installation.
: Can open standard files, process memory, kernel memory, partitions, drives, and specialized formats like S-Record or Intel Hex. Structural Analysis : Includes a Struct Viewer to decode data structures at any address and an Entropy Display
For professional reverse engineers doing large-scale binary analysis with complex data structures, 010 Editor or ImHex might be better due to scripting. But for 99% of hex editing tasks, Helium is faster, lighter, and free.